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KMID : 1189420160290030150
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2016 Volume.29 No. 3 p.150 ~ p.158
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The Effect of Gyejakjimo-tang on c-Fos Expression in Mice Model of Acute Pain
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Noh Hee-Youb
Kim Youn-Sub
Kim Do-Hoon
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Abstract
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Objectives : We want to know the effect of Gyejakjimo-tang in mice model of acute pain.
Methods : We investigated writhing reflex in mice with acetic acid-induced abdominal pain using mice, we observed c-Fos protien expression by immunohistochemistry dyeing method in the paraventricular nucleus(PVN) and supraoptic nucleus(SON) of the hypothalamus.
Results : All of Gyejakjimo-tang treated group suppressed acetic acid-induced writhing response as acetic acid injuction group, but in 100㎎/㎏ Gyejakjimo-tang treated group and 200㎎/㎏ Gyejakjimo-tang treated groups represernted significance. All of Gyejakjimo-tang treated groups(50, 100 and 200㎎/㎏ Gyejakjimo-tang-treated group), Fos-positive cells in PNV significantly decreased as acetic acid injuction group, and All of Gyejakjimo-tang-treated groups Fos-positive cells in SON significantly decreased as acetic acid injuction group.
Conclusions : The present results showed that the mice pre-treated with the aqueous extract of Gyejakjimo-tang showed analgesic effect on acetic acid-induced abdominal pain.
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KEYWORD
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Gyejakjimo-tang, pain, acetic acid, c-Fos
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